Alex Howard Group
October 9, 2026

Why Chronic Fatigue Keeps Coming Back: The Hormone & Histamine Connection

If you live with complex fatigue, you'll probably know the pattern all too well: you start to improve, you get a taste of feeling better, and then the rug is pulled out from under you again. Crash, recover, crash.

It's exhausting and demoralising. But there may be a biochemical reason behind it, and understanding it is the first step towards breaking the cycle.

In our latest video, we explore one of these "perpetuating loops" using perimenopause as an example.

You’ll learn about:

  • Why complex fatigue can follow a crash-and-recovery pattern
  • How perimenopause may influence chronic fatigue
  • The relationship between oestrogen, progesterone and histamine
  • How inflammation may affect mitochondrial function and ATP production
  • Why fatigue and histamine-related symptoms can become a perpetuating loop

If you are familiar with the crash, recover, crash cycle, and would like to learn more about how our team might be able to help you, please book a free discovery call today.

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