Chronic fatigue underwent a second look in 2004 when Peckerman et al discovered that these patients experience lowered cardiac output than normal. What this says is that in chronic fatigue patients instead of producing 5 Litres of blood pumping through the heart per minute while standing only 3.7 Litres are produced. This reduced output of blood results in a lowered concentration of oxygen to the bodies major organs. This answered the question why a large percentage of chronic fatigue patients felt better lying down rather than standing. Peckerman et al concluded that chronic fatigue syndrome was a mild form of heart failure. The heart failure found in chronic fatigue disease is not related to a poor blood supply or blocked arteries; it is instead a result of poor Mitrochondrial function.Mitochondria are present in all cells of the body. They are responsible for the cells ability to generate energy by the use of adenosine triphosphate (ATP). This lets the muscles expand and contract. When the mitochondria in the heart are affected cardiomyopathy occurs in these patients. It is believed that mitochondria dysfunction is the cause of chronic fatigue syndrome.Causes of Mitrochondrial dysfunction are pollution from the environment. Patients that were found to have high percentages of copper, nickel, cadmium, flame retardant, pesticides, and mercury were present with this condition. These metals become toxic and prevent the mitochondria from functioning properly. The solution is to eliminate them in patients suffering from chronic fatigue. Another cause of Mitrochondrial malfunction is that some humans are not as adaptable to their environment as others. The exposure to pollutants, pesticides, stress, poor diet, bacteria and virus can be contributed so some chronic fatigue causes, but not allLowered immunity caused by viruses and stress will deplete the cells Mitrochondrial function. If viral infections are left unchecked or chronic stress is apparent all of the major organs and bodily processes will be affected in order of priority.The first to be affected is the skin. Intolerance to cold will develop, as the skin will no longer have the energy to warm itself due to poor blood supply.The second system to be affected is the muscles. A comprised muscle will release lactic acid and if the immune system can no longer carry it away chronic pain will occur.The third system altered by Mitrochondrial dysfunction is the liver and gut. Toxins will build as a result of poor blood supply and these toxins will continue to cycle through the body.The fourth system is the brain. Poor blood supply results in substandard concentration and memory.The fifth system to be affected is the heart. Dysrhythmias occur as the electrical conductivity becomes disturbed. Chronic muscle fatigue patients commonly complain of heart palpitations or missed heartbeats.The sixth system to be affected by Mitrochondrial dysfunction is the kidney and lungs. This system has an internal regulator to keep blood pressure stable so kidney failure in chronic fatigue patients is rare.A test for Mitrochondrial function has been developed by Acumen labs. The first part is a blood test called Chronic Fatigue Syndrome Profile and it measures the levels of D Ribose, Carnitine, Vitamin B 3, Co-enzyme A, Magnesium, and Superoxide dismutase. The second part of the test determines what may be blocking the Mitrochondrial function. The results of this two-part test can determine areas where patients with Mitrochondrial dysfunction can focus on and improve the quality of their life.